The effects of heparin and extracorporeal circulation on platelet counts and platelet microaggregation during cardiopulmonary bypass
نویسندگان
چکیده
منابع مشابه
Platelet aggregation: effects of cardiopulmonary bypass.
This study was designed to determine whether reduction in platelet aggregate microembolization during the first 30 minutes of cardiopulmonary bypass is due to thrombocytopenia or to decreased ability of platelets to aggregate. The total volume of platelet aggregates induced in blood by adenosine diphosphate (ADP) was measured with a Coulter counter. The volume of platelets in blood was calculat...
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15 صفحه اولThromboxane synthesis and platelet protein release during simulated extracorporeal circulation.
Platelet secretion induced by certain soluble aggregating agents is associated with thromboxane formation. Activation of platelets by artificial surfaces may involve similar biochemical pathways. Therefore. we monitored platelet release and formation of thromboxane B2. the stable endproduct of thromboxane A2, during simulated extracorporeal circulation where contact between blood and synthetic ...
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Albumin decreases polymer surface affinity for platelets, and prostaglandin (PG) E1 prevents surface-induced platelet activation. PGI2, like PGE1, inhibits platelet function but is unstable in vitro. We evaluated the ability of surface-adsorbed albumin and circulating PGI2 to prevent platelet alterations during simulated extracorporeal circulation. Fresh heparinized human blood (500 ml) was rec...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2000
ISSN: 0022-5223
DOI: 10.1067/mtc.2000.108164